Drug Delivery Resources
Explore articles, data sheets, presentations, and posters about Secant Group’s controlled release platform for drug delivery poly(glyercol sebacate) urethane (PGSU). Secant Group’s Hydralese™ technology consists of biocompatible and shelf-stable polymers that can be manufactured into a variety of forms such as implants, microspheres, gastroretentive devices, and coatings, and represents a new alternative excipient for long-acting drug delivery.
Articles
- Co-delivery of an HIV prophylactic and contraceptive using PGSU as a long-acting multipurpose prevention technology (2023)
- Advancing Pharma and Medical Device Development with Novel Biomaterials (2021)
- How a Novel Polymer Can Bring Long-acting Therapeutics to Patients (2021)
- Next-Generation Long-acting Implantables Using Surface-eroding Elastomers (2020)
- Biodegradable Urethane’s Potential for Drug-delivery Implants (2020)
Data Sheets
Presentations
- Improving Long-acting Dosage Forms with Biomaterials Innovation (PODD 2022)
- Elastomeric and Biodegradable Hydralese™ (PGSU) Facilitates Novel Long-acting Oral Gastroretentive Devices and Injectable Microspheres (CRS 2022)
- Breaking the Norm: Showcasing Hydralese™ as a Superior Polymer in Long-acting Drug Delivery (ACS 2022)
- Next-Generation Long-acting Dosage Forms Using Hydralese™ (PGSU) Surface-Eroding Elastomers (PODD 2021)
(Password: PODD2021Day1Videos) - Launching a New Polymer for Controlled Release: Challenges, De-risking, and Breaking Through Historical Precedent (CRS 2021)
(Presentation begins at 4:41) - Development of Long-acting Implantable Drug Delivery Systems Using Hydralese™ (LAII 2020)
Posters
- Content Uniformity, Drug Quantification and Cross-reactivity Analysis of Protein Loaded PGSU Implants Using Raman Spectroscopy and Reverse-Phase High Performance Liquid Chromatography (RP-HPLC) (AAPS 2023)
- Drug-loaded Hydralese™ Poly(Glycerol Sebacate) Urethane Elastomers as Intra-vitreal Microdevices for Ocular Drug Delivery Applications Presenter: Stephanie Reed, PhD; Director, Translational Product Development, Secant Group (AAPS 2022)
- Small-Scale, Rapid Prototyping of Hydralese™ (PGSU) (poly(glycerol sebacate) urethane) Microdevices for Controlled Drug Delivery in Ocular Implants Presenter: Dennis Carney, Senior Engineer, Secant Group (AAPS 2022)
- Expandable Single-Component Gastroretention Devices: Shape Optimization & Proof of Concept for Extended Gastric Residency and Drug Release In Vivo (AAPS 2022)
- Textile-reinforced Hydralese™ Leaflets with High Toughness and Low Flexural Stiffness (ISACB 2022)
- Transmission Raman Microscopy as a Process Analytical Technique for Drug-loaded Hydralese™ (PGSU) Elastomers (AAPS 2021)
- Retrievability, IVIVC, and Biocompatibility of a 2’-deoxyadenosine-loaded Hydralese™ (PGSU) Implant (AAPS 2021)
- Biodegradable Hydralese™ (PGSU) Microspheres for Controlled Release of Water-soluble Drugs (AAPS 2021)
- Reaction Injection Molding Scale-up of Hydralese™ (PGSU) Rods for Controlled Drug Delivery (AAPS 2021)
- Expandable Single-component Gastroretention Devices for Extended Drug Delivery Using Biodegradable Elastomer Hydralese™ (PGSU) (AAPS 2020)
- Biodegradable Hydralese™ (PGSU) Microspheres for Controlled Drug Delivery (AAPS 2020)
- Zero-order Release of Hydrophilic Drugs at High Loadings Using Novel Biodegradable Elastomer Hydralese™ (PGSU) (AAPS 2020)
- Ultra-long-acting Oral Drug Delivery Using a Single-component Hydralese™ (PGSU) Gastroretentive Device (AAPS 2020)
- Long-acting Implantables Using Surface-eroding Elastomers Sustain Zero-order, Multi-month Release (LAII 2020)
- Surface-eroding Elastomer Exhibits Zero-order Release in Highly Loaded LAIs (AAPS 2019)
- Next-generation Long-acting Implantables Using Surface-eroding Elastomers (CRS 2019)
